Identification and Role of Muscarinic Receptor Subtypes Expressed in Rat Adrenal Medullary Cells
نویسندگان
چکیده
منابع مشابه
Muscarinic receptor-mediated increase in cyclic GMP level in isolated bovine adrenal medullary cells.
Adrenal medulla is regarded as a model of neurons containing catecholamine (CA), and is the most suitable tissue for studying the regulation of CA release and synthesis. Recently, some investigations have been carried out on these problems using isolated adrenal medullary cells [ 141. Such preparations are suitable for use in elucidating how stimulation of membrane receptors is coupled with rel...
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Up to date, there are four pharmacologically characterized subtypes of muscarinic receptors (M1, M2, M3 and M4). In our study we have investigated muscarinic receptor subtypes in smooth muscle layers of human stomach. Isolated preparations of longitudinal and circular muscle layers from human stomach were used. Acetylcholine, bethanechol, carbachol, pilocarpine and AHR -602 produced concen...
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Muscarinic receptor subtypes in the airways appear to subserve different physiological functions. M1-receptors facilitate neurotransmission through parasympathetic ganglia and enhance cholinergic reflexes, but are also localized to alveolar walls. M2-receptors act as autoreceptors on post-ganglionic cholinergic nerves and inhibit acetylcholine release. There is some evidence that they may be de...
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Neuronal nicotinic acetylcholine receptors (nAChRs) expressed on mesostriatal dopaminergic neurons are thought to mediate several behavioral effects of nicotine, including locomotion, habit learning, and reinforcement. Using immunoprecipitation and ligand-binding techniques, we have shown that both alpha6beta2* and alpha4(nonalpha6)beta2* nAChRs are expressed in the caudate-putamen and that onl...
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Table 1 also shows that cyclic AMP concentrations were increased to the same extent by PGE2 and 3-isobutyl-1methyl xanthine, but that PGEz was a much less potent stimulator of mucin release. Thus our results have demonstrated a lack of correlation between magnitude of increase in cyclic AMP concentration and degree of stimulation of mucin secretion. They suggest that increased cyclic AMP concen...
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ژورنال
عنوان ژورنال: Journal of Pharmacological Sciences
سال: 2011
ISSN: 1347-8613,1347-8648
DOI: 10.1254/jphs.11125fp